NEW YORK, USA (AP) — Bothered by the heat and stifling humidity, Eugenie Bouchard felt dizzy and her vision was blurry.

She got her blood pressure checked. Plastic bags filled with ice were rubbed on her shoulders, arms and legs during a second-set medical time-out.

Bouchard tried to carry on, but it was hardly an ideal time to try to win a tennis match. The number seven-seeded Bouchard became the latest top woman to bow out at this surprise-filled US Open, beaten 7-6 (2), 6-4 yesterday by 17th-seeded Ekaterina Makarova of Russia in the fourth round.

It ended Bouchard’s streak of making at least the semi-finals at each Grand Slam tournament this year. That included a runner-up finish at Wimbledon in July; the 20-year-old Canadian is only 4-4 since then.

The top-seeded man, Novak Djokovic, played mostly mistake-free tennis, making only 19 unforced errors and facing only two break points — both saved — in a 6-1, 7-5, 6-4 victory over 22nd-seeded Philipp Kohlschreiber of Germany.

Djokovic now meets two-time major champion Andy Murray, who got past number nine Jo-Wilfried Tsonga 7-5, 7-5, 6-4.

In fourth-round men’s matches last night, number three Stan Wawrinka brushed off a tumble into the stands and beat number 16 Tommy Robredo 7-5, 4-6, 7-6 (7), 6-2.

Williams got to her first Grand Slam quarter-final of 2014 by overwhelming 50th-ranked Kaia Kanepi of Estonia 6-3, 6-3 yesterday.